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KMID : 0191120200350170148
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Journal of Korean Medical Science
2020 Volume.35 No. 17 p.148 ~ p.148
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Association between ALDH2 Polymorphism and Gastric Cancer Risk in a Korean Population
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Choi Chang-Kyun
Kweon Sun-Seog
Cho Sang-Hee
Kim Hye-Yeon
Shin Min-Ho
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Abstract
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The association between alcohol and gastric cancer is stronger in East Asians than in other ethnic groups, presumably due to an aldehyde dehydrogenase 2 (ALDH2) polymorphism. Therefore, we investigated the relationship between the ALDH2 rs671 polymorphism and gastric cancer in a Korean population. This case-control study included 3,245 hospital patients newly diagnosed with gastric cancer and 8,732 population controls. The ALDH2 rs671 genotype was classified as inactive ALDH2 (GG) or active ALDH2 (GA/AA). The risk of gastric cancer was higher in men with the inactive ALDH2 than in those with active ALDH2 (odds ratio [OR], 1.25; 95% confidence interval [CI], 1.09?1.39), whereas no significant association was found between ALDH2 genotype and gastric cancer in women (OR, 1.00; 95% CI, 0.99?1.02). In men, the association between ALDH2 genotype and gastric cancer was stronger in current drinkers. Our findings support the previously reported association between inactive ALDH2 and high risk of gastric cancer.
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KEYWORD
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Gastric Cancer, Alcohol Drinking, ALDH2
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